Attach the backup disk to your computer
See the Choosing a backup volume section for additional advice on this subject.
Format the disk
Before you can use a new disk for a backup of macOS, you must first initialize it with the correct format using the Disk Utility application.
Launch Carbon Copy Cloner
Applications > Carbon Copy Cloner
Select the Source
Click on the dotted box under the SOURCE heading to view available sources.
Select your startup disk from the menu of available volumes for the source.
Select the Destination
Click on the dotted box under the DESTINATION heading to view available destinations, then select your new backup drive from the menu of available volumes for the destination.
Begin the Clone
Congratulations - your first clone is in progress!
If you run the same backup task again, CCC will copy only the items that have changed. There's no special setting to achieve this behavior, simply click the Clone button again or configure your backup task to run automatically on a scheduled basis.